Class: Antibacterials
ATC Class: J01AA08
VA Class: OR900
Brands: Arestin
Introduction
Antibacterial; tetracycline antibiotic.
Uses for Minocycline (EENT)
Periodontitis
Used subgingivally for treatment of adult periodontitis as an adjunct to scaling and root planing procedures to reduce pocket depth.
Minocycline (EENT) Dosage and Administration
Administration
Subgingival Administration
Administered subgingivally as extended-release powder into periodontal pockets by a dental health-care professional.
Administration does not require local anesthesia.
Extended-release preparation is bioresorbable and does not need to be manually removed.
Subgingival Administration Technique
A unit-dose cartridge containing minocycline extended-release dry powder must be inserted into a spring-loaded cartridge handle prior to administration. The handle mechanism should be sterilized prior to reuse on another patient.
Administer by inserting the unit-dose cartridge into the base of the periodontal pocket and then pressing the thumb ring in the handle mechanism to expel the powder while gradually withdrawing the tip from the base of the pocket.
No dental adhesive or periodontal dressing is required following subgingival administration.
Consult manufacturer's information for additional information regarding subgingival administration of minocycline extended-release powder.
Dosage
Available as minocycline hydrochloride; dosage expressed in terms of minocycline.
Each commercially available unit-dose cartridge delivers 1 mg of minocycline.
Adults
Periodontitis
Subgingival
Dosage varies depending on the size, shape, and number of periodontal pockets treated.
In clinical trials, up to 122 unit-dose cartridges were used during a single visit to treat all pocket sites with probing depth ≥5 mm and up to 3 treatments were administered at interva...
