Mintezol

Generic name: thiabendazole
Dosage form: Chewable Tablets and Suspension
Drug class:Anthelmintics

Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.

Mintezol Description

Mintezol1 (Thiabendazole) is an anthelmintic provided as 500 mg chewable tablets, and as a suspension, containing 500 mg thiabendazole per 5 mL. The suspension also contains sorbic acid 0.1% added as a preservative. Inactive ingredients in the tablets are acacia, calcium phosphate, flavors, lactose, magnesium stearate, mannitol, methylcellulose, and sodium saccharin. Inactive ingredients in the suspension are an antifoam agent, flavors, polysorbate, purified water, sorbitol solution, and tragacanth.

Thiabendazole is a white to off-white odorless powder with a molecular weight of 201.26, which is practically insoluble in water but readily soluble in dilute acid and alkali. Its chemical name is 2-(4-thiazolyl)-1H -benzimidazole. The empirical formula is C10H7N3S and the structural formula is:

1

Registered trademark of MERCK & CO., Inc. COPYRIGHT © MERCK & CO., Inc., 1983 All rights reserved

CLINICAL PHARMACOLOGY

In man, thiabendazole is rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. It is metabolized almost completely to the 5-hydroxy form which appears in the urine as glucuronide or sulfate conjugates. In 48 hours, about 5% of the administered dose is recovered from the feces and about 90% from the urine. Most is excreted in the first 24 hours.

Mechanism of Action

The precise mode of action of thiabendazole on the parasite is unknown, but it may inhibit the helminth-specific enzyme fumarate reductase.

Thiabendazole is vermicidal and/or vermifugal against Ascaris lumbricoides (“common roundworm”), Strongyloides stercoralis (threadworm), Necatoramericanus, and Ancylostoma duodenale (hookworm), Trichuri...