Mitapivat (Oral)
Medically reviewed by Drugs.com. Last updated on Mar 26, 2022.
Commonly used brand name(s)
In the U.S.
- Pyrukynd
- Pyrukynd Taper Pack
Available Dosage Forms:
- Tablet
Uses for mitapivat
Mitapivat is used to treat hemolytic anemia (low number of red blood cells caused by early breakdown of red blood cells) in patients with pyruvate kinase (PK) deficiency.
Mitapivat is available only with your doctor's prescription.
Before using mitapivat
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mitapivat, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to mitapivat or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of mitapivat in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mitapivat in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking mitapivat, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using mitapivat with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alfentanil
- Apalutamide
- Aprepitant
- Atazanavir
- Boceprevir
- Bosentan
- Carbamazepine
- Cenobamate
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Desogestrel
- Dienogest
- Digoxin
- Diltiazem
- Dronedarone
- Drospirenone
- Efavirenz
- Enzalutamide
- Erythromycin
- Estetrol
- Estradiol
- Ethinyl Estradiol
- Ethynodiol
- Etonogestrel
- Etravirine
- Fluconazole
- Fluvoxamine
- Fosnetupitant
- Fosphenytoin
- Gestodene
- Idelalisib
- Imatinib
- Indinavir
- Itraconazole
- Ketoconazole
- Letermovir
- Levonorgestrel
- Lopinavir
- Lorlatinib
- Lumacaftor
- Medroxyprogesterone
- Mestranol
- Mitotane
- Modafinil<...
