Mitomycin (Intravenous)
Medically reviewed by Drugs.com. Last updated on Dec 31, 2021.
Mitomycin should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of therapy and complications is possible only when adequate diagnostic and treatment facilities are readily available. Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of mitomycin. Hemolytic Uremic Syndrome (HUS), a serious complication of chemotherapy consisting primarily of microangiopathic hemolytic anemia, thrombocytopenia, and irreversible renal failure, has been reported in patients receiving systemic mitomycin. The syndrome may occur at any time during systemic therapy with mitomycin as a single agent or in combination with other cytotoxic drugs; however, most cases occur at doses greater than or equal to 60 mg of mitomycin. Blood product transfusion may exacerbate the symptoms associated with this syndrome. The incidence of the syndrome has not been defined .
Commonly used brand name(s)
In the U.S.
- Mutamycin
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Antineoplastic Agent
Uses for mitomycin
Mitomycin belongs to the group of medicines known as antineoplastics. It is used to treat some kinds of cancer.
Mitomycin interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by mitomycin, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.
Before you begin treatment with mitomycin, you and your doctor should talk about the good mitomycin will do as well as the risks of using it.
Mitomycin is to be administered only by or under the immediate supervision of your doctor.
Before using mitomycin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mitomycin, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to mitomycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Although there is no specific information comparing use of mitomycin in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults.
Geriatric
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of mitomycin in the elderly with use in other age groups.
Breastfeeding
There are no adequate studies in wo..
