Mivacron
Generic name:mivacurium chloride
Dosage form: injection
Drug class:Neuromuscular blocking agents
Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.
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This drug should be administered only by adequately trained individuals familiar with its actions, characteristics, and hazards.
The Mivacron brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Mivacron Description
Mivacron (mivacurium chloride) is a short-acting, nondepolarizing skeletal muscle relaxant for intravenous (IV) administration. Mivacurium chloride is [R-[R*,R*-(E)]]-2,2'-[(1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride. The molecular formula is C58H80Cl2N2O14 and the molecular weight is 1100.18. The structural formula is:
The partition coefficient of the compound is 0.015 in a 1-octanol/distilled water system at 25°C.
Mivacurium chloride is a mixture of three stereoisomers: (1R,1'R , 2S, 2'S ), the trans-trans diester; (1R,1'R , 2R, 2'S ), the cis-trans diester; and (1R,1'R , 2R, 2'R ), the cis-cis diester. The trans-trans and cis-trans stereoisomers comprise 92% to 96% of mivacurium chloride and their neuromuscular blocking potencies are not significantly different from each other or from mivacurium chloride. The cis-...
