Mobocertinib
Generic name: mobocertinib
Brand name: Exkivity
Dosage form: oral capsule
Drug class:EGFR inhibitors
What is mobocertinib?
Mobocertinib is a type of drug called a kinase inhibitor, which is used to treat a rare type of non-small cell lung cancer (NSCLC).
Mobocertinib is used to treat NSCLC caused by a specific type of gene mutation called an epidermal growth factor receptor (EGFR) exon 20 insertion mutation. Only about 2000 to 4000 people are diagnosed with this type of cancer in the US each year.
EGFR is a protein that helps cells to grow and divide. When an exon 20 insertion mutation occurs, it drives cells to grow and divide abnormally, causing an EGFR-positive cancer.
Mobocertinib works by binding to and blocking EGFR exon 20 insertion mutations, which helps to slow the growth of cancer cells.
Mobocertinib was granted accelerated approval by the US Food and Drug Administration (FDA) in 2021. It is used with the Oncomine Dx Target Test, which identifies patients with exon 20 insertion mutations.
What is mobocertinib used for?
Mobocertinib is a prescription medicine used to treat adults with NSCLC:
- that is locally advanced or has spread to other parts of the body (metastatic) and cannot be removed by surgery, and
- has an abnormal EGFR gene caused by an exon 20 insertion mutation
- whose disease has worsened while on or after chemotherapy that contains platinum
Your healthcare provider will perform a test to make sure that mobocertinib is right for you.
It is not known if mobocertinib is safe and effective in children.
Important information
Mobocertinib may cause serious side effects, including:
- Changes in the electrical activity of your heart called QTc prolongation and Torsades de Pointes. QTc prolongation can cause irregular heartbeats that can be life-threatening and may lead to death. Your healthcare provider will check the electrical activity of your heart with a test called an electrocardiogram (ECG) and do blood tests to check your electrolytes before starting and during treatment with mobocertinib. Tell your healthcare provider right away if you feel dizzy, lightheaded, faint or have an irregular heartbeat.
See "What are the side effects of mobocertinib?" below for more information about side effects.
What should I tell my doctor before taking mobocertinib?
Before taking mobocertinib, tell your healthcare provider about all of your medical conditions, including if you:
- have heart problems, including a condition called long QTc syndrome
- have problems with your electrolytes, such as sodium, potassium, calcium or magnesium
- have lung or breathing problems other than lung cancer
How should I take mobocertinib?
- Take mobocertinib exactly as your healthcare provider tells you to take it.
- Take your prescribed dose of mobocertinib 1 time each day.
- Take mobocertinib with or without food.
- Swallow mobocertinib capsul...
