Mometasone

Class: Adrenals
VA Class: RE101
Chemical Name: (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Molecular Formula: C₂₇H₃₀Cl₂O₆
CAS Number: 83919-23-7
Brands: Asmanex HFA, Asmanex Twisthaler

Medically reviewed by Drugs.com on Nov 1, 2021. Written by ASHP.

Introduction

Synthetic nonfluorinated glucocorticoid.

Uses for Mometasone

Asthma

Mometasone: Maintenance treatment of asthma as prophylactic therapy.

Mometasone in fixed combination with formoterol (mometasone/formoterol): Treatment of asthma in patients not responding adequately to long-term asthma controller therapy (e.g., inhaled corticosteroids) or whose disease severity warrants initiation of treatment with both an inhaled corticosteroid and a long-acting β₂-adrenergic agonist.

Mometasone alone or in fixed combination with formoterol: Not indicated for treatment of acute bronchospasm (i.e., as rescue therapy for treatment of acute episodes of bronchospasm).

Mometasone Dosage and Administration

General

• Adjust dosage carefully according to individual requirements and response.

• After a satisfactory response is obtained, decrease dosage gradually to the lowest dosage that maintains an adequate clinical response. Achieve the lowest effective dosage, particularly in children, since inhaled corticosteroids have the potential to affect growth. (See Pediatric Use under Cautions.)

• Base initial and maximum dosages in adults and children ≥12 years of age on previous asthma therapy.

Conversion to Orally Inhaled Therapy in Patients Receiving Systemic Corticosteroids

• When switching from systemic corticosteroids to orally inhaled corticosteroids, including mometasone, asthma should be reasonably stable before initiating oral inhalation treatment.

• Initially, administer oral ...