Muromonab-cd3 (Intravenous)
Medically reviewed by Drugs.com. Last updated on Feb 2, 2022.
Anaphylactic and anaphylactoid reactions may occur following administration of any dose. Serious, occasionally life-threatening or lethal, systemic, cardiovascular, and central nervous system reactions have been reported. These have included: pulmonary edema, especially in patients with volume overload; shock; cardiovascular collapse; cardiac or respiratory arrest; seizures; coma; cerebral edema; cerebral herniation; blindness; and paralysis. Monitor fluid status prior to and during treatment and premedicate with methylprednisolone to minimize symptoms of Cytokine Release Syndrome .
Commonly used brand name(s)
In the U.S.
- Orthoclone OKT 3
Pharmacologic Class: Monoclonal Antibody
Uses for muromonab-cd3
Muromonab-CD3 is a monoclonal antibody. It is used to reduce the body's natural immunity in patients who receive organ (for example, kidney) transplants.
When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Muromonab-CD3 works by preventing the white blood cells from doing this.
The effect of muromonab-CD3 on the white blood cells may also reduce the body's ability to fight infections. Before you begin treatment, you and your doctor should talk about the good muromonab-cd3 will do as well as the risks of using it.
Muromonab-CD3 is to be administered only by or under the immediate supervision of your doctor.
Before using muromonab-cd3
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For muromonab-cd3, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to muromonab-cd3 or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
There is no specific information comparing use of muromonab-CD3 in children with use in other age groups. However, children are more likely to get dehydrated from the diarrhea and vomiting that may be caused by muromonab-cd3.
Geriatric
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of muromonab-CD3 in the elderly with use in other age groups.
Breastfeeding
Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using muromonab-cd3.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking muromonab-cd3, it is especially important that your healthcare professional know if you are taking any of the medicines..
