Myfembree

Generic name:relugolix, estradiol and norethindrone acetate
Dosage form: tablets
Drug class:Sex hormone combinations

Medically reviewed by Judith Stewart, BPharm. Last updated on Sep 1, 2021.

Important information

Myfembree may cause serious side effects, including:

• cardiovascular conditions
  • Myfembree may increase your chances of heart attack, stroke, or blood clots, especially if you are over 35 years of age, smoke, and have uncontrolled high blood pressure. Stop treatment and call your healthcare provider right away or go to the nearest hospital emergency room right away if you have:
    • leg pain or swelling that will not go away
    • sudden shortness of breath
    • double vision, bulging of the eyes, sudden blindness, partial or complete
    • pain or pressure in your chest, arm, or jaw
    • sudden, severe headache unlike your usual headaches
    • weakness or numbness in an arm or leg, or trouble speaking
• bone loss (decreased bone mineral density)
  • While you are taking Myfembree, your estrogen levels may be low. Low estrogen levels can lead to bone mineral density loss.
  • If you have bone loss on Myfembree, your bone density may improve after you stop taking Myfembree, but complete recovery may not occur. It is unknown if these bone changes could increase your risk for broken bones as you age. For this reason, you should not take Myfembree for more than 24 months.
  • Your healthcare provider may order an X-ray test called a DXA scan to check your bone mineral density when you start treatment and periodically after you start.
  • Your healthcare provider may advise you to take vitamin D and/or calcium supplements as part of a healthy lifestyle that promotes bone health. If you are also advised to take iron supplements, they should be taken at least two hours apart from your vitamin D or calcium supplements.
• effects on pregnancy
  • Do ..