Mytelase

Generic name: ambenonium chloride
Dosage form: tablet
Drug class:Cholinergic muscle stimulants

Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.

Mytelase Description

Mytelase, brand of ambenonium chloride, is [Oxalylbis (iminoethylene)] bis[(o-chlorobenzyl) diethylammonium] dichloride, a white crystalline powder, soluble in water to 20 percent (w/v).

Inactive Ingredients: Acacia, Dibasic Calcium Phosphate, Gelatin, Lactose, Magnesium Stearate, Starch, Sucrose.

Mytelase - Clinical Pharmacology

The compound is a cholinesterase inhibitor with all the pharmacologic actions of acetylcholine, both the muscarinic and nicotinic types. Cholinesterase inactivates acetylcholine. Like neostigmine, Mytelase suppresses cholinesterase but has the advantage of longer duration of action and fewer side effects on the gastrointestinal tract. The longer duration of action also results in more even strength, better endurance, and greater residual effect during the night and on awakening than is produced by shorter-acting anticholinesterase compounds.

INDICATION AND USAGE

This drug is indicated for the treatment of myasthenia gravis.

Contraindications

Routine administration of atropine with Mytelase is contraindicated since belladonna derivatives may suppress the parasympathomimetic (muscarinic) symptoms of excessive gastrointestinal stimulation, leaving only the more serious symptoms of fasciculation and paralysis of voluntary muscles as signs of overdosage.

Mytelase should not be administered to patients receiving mecamylamine, or any other ganglionic blocking agents. Mytelase should also not be administered to patients with a known hypersensitivity to ambenonium chloride or any other ingredients of Mytelase.

Warnings

Because this drug has a more prolonged action than other antimyasthenic drugs, simultaneous administration with other cholinergics is contraindicated except under strict medical supervision. The overlap in duration of action of several drugs complicates dosage schedules. Therefore, when a patient is to be given the drug, the administration of all other cholinergics should be suspended until the patient has been stabilized. In most instances the myasthenic symptoms are effectively controlled by its use alone.

Precautions

Great care and supervision are required, since the warning of overdosage is mini...