Naturetin

Generic name:bendroflumethiazide
Dosage form: Tablets USP
Drug class:Thiazide diuretics

Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.

Naturetin Description

Naturetin (Bendroflumethiazide Tablets USP) is a benzothiadiazine derivative containing a benzyl and trifluoromethyl group. It is a potent oral diuretic and antihypertensive agent. Bendroflumethiazide is designated chemically as 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its structural formula is

C15H14F3N3O4S2 MW=421.41

It is available as compressed tablets providing 5 or 10 mg bendroflumethiazide. Inactive ingredients: microcrystalline cellulose, colorants [D&C Yellow No. 10; FD&C Blue No.1 for 5 mg only, and FD&C Yellow No. 6 for 10 mg only], lactose, magnesium stearate, sodium starch glycolate, and pregelatinized starch.

Naturetin - Clinical Pharmacology

Thiazides affect the renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage all thiazides are approximately equal in their diuretic potency.

Thiazides increase excretion of sodium and chloride in approximately equivalent amounts. Natriuresis causes a secondary loss of potassium and bicarbonate.

The mechanism of the antihypertensive effect of thiazides is unknown. Thiazides do not affect normal blood pressure.

Onset of action of thiazides occurs in two hours and the peak effect at about four hours. Duration of action persists for approximately six to 12 hours. Thiazides are eliminated rapidly by the kidney.

Indications and Usage for Naturetin

Naturetin is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

Naturetin has also been found useful in edema due to various forms of renal dysfunction such as: nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

Naturetin tablets are indicated in the management of hypertension either as the sole therapeutic agen...