Nedocromil (EENT)

Class: Antiallergic Agents
- Mast-cell Stabilizers
Chemical Name: 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Molecular Formula: C₁₉H₁₇NO₇
CAS Number: 69409-73-6
Brands: Alocril

Medically reviewed by Drugs.com on Aug 23, 2021. Written by ASHP.

Introduction

Mast-cell stabilizer.

Uses for Nedocromil (EENT)

Allergic Conjunctivitis

Symptomatic treatment of ocular itching associated with allergic conjunctivitis.

Nedocromil (EENT) Dosage and Administration

Administration

Ophthalmic Administration

Apply topically to the eye as an ophthalmic solution. Administer at regular intervals.

If more than 1 topical ophthalmic drug is used, administer the drugs at least 10–15 minutes apart.

Avoid contamination of the solution container.

Continue therapy throughout period of exposure (i.e., until pollen season is over or until exposure to offending allergen is terminated), even in absence of symptoms.

Dosage

Available as nedocromil sodium; dosage expressed in terms of the salt.

Pediatric Patients

Allergic Conjunctivitis

Ophthalmic

Children ≥3 years of age: 1 or 2 drops of a 2% solution in each eye twice daily.

Adults

Allergic Conjunctivitis

Ophthalmic

1 or 2 drops of a 2% solution in each eye twice daily.

Cautions for Nedocromil (EENT)

Contraindications

• Known hypersensitivity to nedocromil or any ingredient in the formulation.

Warnings/Precautions

General Precautions

Administration

For topical ophthalmic use only.

Specific Populations

Pregnancy

Category B.

Lactation

Distributed into milk in rats following IV administration; not known whether distributed into human milk. Use with caution.

Pediatric Use

Safety and efficacy not established in children <3 years of age.

Geriatric Use

No substantial differences in safety and efficacy relative to younger adults.

Common Adverse Effects

Headache, ocular discomfort (i.e., burning, irritation, stinging ), unpleasant taste, nasal congestion.

Interactions for Nedocromil (EENT)

No formal drug interaction studies to date.

Nedocromil (EENT) Pharmacokinetics

Absorption

Bioavailability

Minimally absorbed (<4%) following topical application to the eye.

Onse..