Neomycin and Polymyxin B Sulfates

Generic name: neomycin sulfate and polymyxin b
Dosage form: solution for irrigation
Drug class:Topical antibiotics

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Neomycin and Polymyxin B Sulfates Description

Neomycin and Polymyxin B Sulfates Solution for Irrigation is a concentrated sterile antibiotic solution to be diluted for urinary bladder irrigation. Each mL contains neomycin sulfate equivalent to 40 mg neomycin base, 200,000 units polymyxin B sulfate, and water for injection.

Neomycin sulfate, an antibiotic of the aminoglycoside group, is the sulfate salt of neomycin B and C produced by Streptomyces fradiae. It has a potency equivalent to not less than 600µg of neomycin per mg. The structural formulae are:

Polymyxin B sulfate, a polypeptide antibiotic, is the sulfate salt of polymyxin B1 and B2 produced by the growth of Bacillus polymyxa. It has a potency of not less than 6,000 polymyxin B units per mg. The structural formulae are:

Neomycin and Polymyxin B Sulfates - Clinical Pharmacology

After prophylactic irrigation of the intact urinary bladder, neomycin and polymyxin B are absorbed in clinically insignificant quantities. A neomycin serum level of 0.1 µg/mL was observed in three of 33 patients receiving the rinse solution. This level is well below that which has been associated with neomycin-induced toxicity.

When used topically, polymyxin B sulfate and neomycin are rarely irritating.

Microbiology: The prepared Neomycin and Polymyxin B Sulfates Solution for Irrigation solution is bactericidal. The aminoglycosides act by inhibiting normal protein synthesis in susceptible microorganisms.

Polymyxins increase the permeability of bacterial cell wall membranes. The solution is active in vitro against

Escherichia coli
Staphylococcus aureus
Haemophilus influenzae
Klebsiella andEnterobacter sepecies
Neisseria species, and
Pseudomonas aeruginosa.