#
Nirmatrelvir
  • Professionals
  • AHFS Monographs

Nirmatrelvir

Class: Antivirals, Miscellaneous
- SARS-CoV-2 Main Protease Inhibitor
- Mpro Inhibitor
- 3CLpro Inhibitor
- Nsp5 Protease Inhibitor
- Viral Protease Inhibitor
Chemical Name: (1R,2S,5S)-N-((1S)-1-Cyano-2-((3S)-2-oxopyrrolidin-3-yl)ethyl)-3-((2S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide]
Molecular Formula: C23H32F3N5O4C37H48N6O5S2
CAS Number: 155213-67-5
Brands: Paxlovid™

Medically reviewed by Drugs.com on Jan 7, 2022. Written by ASHP.

Warning

Special Alerts:

The American Society of Health-System Pharmacists, Inc. represents that the information provided in the accompanying monograph was formulated with a reasonable standard of care, and in conformity with professional standards in the field. Readers are cautioned that a combined regimen of ritonavir-boosted nirmatrelvir is not an approved treatment for coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, but rather, is being investigated for and is currently available under an FDA emergency use authorization (EUA) for the treatment of mild to moderate COVID-19 in certain outpatients. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to the information contained in the accompanying monograph, and specifically disclaims all such warranties. Readers of this information are advised that ASHP is not responsible for the continued currency of the information, for any errors or omissions, and/or for any consequences arising from the use of the information contained in the monograph in any and all practice settings. Readers are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and that the information contained in the monograph is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information contained in the monograph is not a substitute for medical care.

Introduction

Antiviral; SARS-CoV-2 main protease (Mpro) inhibitor.

Uses for Nirmatrelvir

Coronavirus Disease 2019 (COVID-19)

Nirmatrelvir with low-dose ritonavir (ritonavir-boosted nirmatrelvir) is available under an emergency use authorization (EUA) for the treatment of mild to moderate COVID-19 in adults and pediatric patients (≥12 years of age weighing ≥40 kg) with positive results of direct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral testing who are at high risk of progression to severe COVID-19, including hospitalization or death.

Consult nirmatrelvir EUA letter of authorization ([Web]