Nirmatrelvir and ritonavir
Generic name: nirmatrelvir and ritonavir
Brand name: Paxlovid
Dosage form: oral tablet (150 mg-100 mg (300 mg-100 mg Dose))
Drug class:Antiviral combinations
What is nirmatrelvir and ritonavir?
Nirmatrelvir in combination with ritonavir is an experimental medicine being studied for the treatment of mild-to-moderate COVID-19. This drug is still being studied and all of its risks are not yet known.
The US Food and Drug Administration (FDA) has authorized emergency use of nirmatrelvir in combination with another medicine called ritonavir for the treatment of mild-to-moderate COVID-19 in adults and people 12 years of age and older (weighing at least 40 kg or 88 lbs) testing positive for COVID-19, and who are at high risk for progression to severe COVID-19, including hospitalization or death.
Nirmatrelvir and ritonavir is not authorized for use:
for initiation of treatment in people needing hospitalization due to COVID-19;
for prevention before or after exposure of COVID-19; or
longer than 5 consecutive days.
Nirmatrelvir and ritonavir may also be used for purposes not listed in this medication guide.
Warnings
The US Food and Drug Administration (FDA) has authorized emergency use of nirmatrelvir in combination with another medicine called ritonavir for the treatment of mild-to-moderate COVID-19 in adults and people 12 years of age and older (weighing at least 40 kg or 88 lbs).
Before taking this medicine
You should not use nirmatrelvir and ritonavir if you are allergic to it.
Some drugs should not be used with nirmatrelvir and ritonavir, such as those listed below.
sildenafil (Revatio) when used to treat pulmonary arterial hypertension (PAH);
pain medicine--pethidine, piroxicam, propoxyphene;
heart medicine--amiodarone, dronedarone, flecainide, propafenone, quinidine, ranolazine;
antipsychotic medicine--lurasidone, pimozide,
