Nuquin HP Gel

Generic name: hydroquinone
Dosage form: gel
Drug class:Topical depigmenting agents

Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

SKIN BLEACHING TOPICAL GEL WITH SUNSCREENS

Rx only

FOR EXTERNAL USE ONLY: NOT FOR OPHTHALMIC, NASAL, OR OTIC USE.

Nuquin HP Gel Description

Each gram of NUQUIN® HP 4% GEL (Hydroquinone 4%) Contains: ACTIVES: 40 mg of Hydroquinone USP, 50 mg of Padimate O USP and 30 mg of Dioxybenzone USP in a hydroalcoholic base of: INACTIVES: Alcohol, Carbomer, Disodium EDTA, Purified Water, Sodium Metabisulfite and Trolamine. Hydroquinone is 1, 4-Benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C6H6O2 and has a molecular weight of 110.11.

The structural formula is:

C6H602

Nuquin HP Gel - Clinical Pharmacology

Topical application of hydroquinone produces a reversible depigmentation of the skin by the inhibition of the enzymatic oxidation of tyrosine to 3, 4-dihydroxyphenylalanine (dopa) [Denton, C., et al., 19521] and suppression of other melanocyte metabolic processes [Jimbow, K., et al., 19742]. Exposure to sunlight or ultraviolet light will cause repigmentation of the bleached areas [Parrish, J.A. et al., 19783].

Indications and Usage for Nuquin HP Gel

NUQUIN® HP 4% GEL is indicated for the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other und...