Ogestrel 0.5/50
Generic name:norgestrel and ethinyl estradiol
Dosage form: tablets
Drug class:Contraceptives
Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.
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Patients should be counseled that oral contraceptives do not protect against transmission of HIV (AIDS) and other sexually transmitted diseases (STDs) such as chlamydia, genital herpes, genital warts, gonorrhea, hepatitis B, and syphilis.
Ogestrel 0.5/50 Description
Ogestrel® 0.5/50 Tablets (norgestrel and ethinyl estradiol tablets USP, 0.5 mg/0.05 mg) provide an oral contraceptive regimen consisting of 21 white tablets followed by 7 peach inert tablets.
Each white tablet, for oral administration contains 0.5 mg of norgestrel, 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-(±)-, a totally synthetic progestogen, and 0.05 mg ethinyl estradiol, 19-Nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol, and the following inactive ingredients: croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, and povidone.
Each inactive peach tablet, for oral administration, in the 28 day regimen contains the following inactive ingredients: anhydrous lactose, FD&C Yellow No. 6 Lake, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.
NORGESTREL
C21H28O2 MW 312.45
ETHINYL ESTRADIOL
C20H24O2 MW 296.40
Ogestrel 0.5/50 - Clinical Pharmacology
Mode of Action
Combination oral contraceptives act by suppression of gonadotropins. Although the primary mechanism of this action is inhibition of ovulation, other alterations include changes in the cervical mucus (which increase the difficulty of sperm entry into the uterus) and the endometrium (which reduce the likelihood of implantation).
