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Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide
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  • FDA PI

Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide

Dosage form: tablet
Drug class:Miscellaneous antihypertensive combinations

Medically reviewed by Drugs.com. Last updated on Jan 1, 2021.

WARNING: FETAL TOXICITY
  • When pregnancy is detected, discontinue olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets as soon as possible. (5.1, 8.1)
  • Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus. (5.1, 8.1)

Indications and Usage for Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide

Olmesartan medoxomil, amlodipine, hydrochlorothiazide tablets are indicated for the treatment of hypertension, alone or with other antihypertensive agents, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular (CV) events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with olmesartan medoxomil, amlodipine, and hydrochlorothiazide tablets.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Educatio...