Olodaterol
Class: Selective beta-2-Adrenergic Agonists
VA Class: RE102
Chemical Name: 6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]-amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one hydrochloride
Molecular Formula: C21H27ClN2O5
CAS Number: 869477-96-3
Brands: Striverdi Respimat
Warning
Increased risk of asthma-related death with long-acting β2-adrenergic agonists. (See Asthma-related Death under Cautions.)
Increased risk of asthma-related death considered class effect of long-acting β2-adrenergic agonists, including olodaterol.
Safety and efficacy of olodaterol in patients with asthma† not established; olodaterol not indicated for treatment of asthma.
Introduction
Bronchodilator; a relatively selective, long-acting β2-adrenergic agonist.
Uses for Olodaterol
Bronchospasm in COPD
Olodaterol alone or in fixed combination with tiotropium used for long-term maintenance treatment of airflow obstruction associated with COPD, including chronic bronchitis and emphysema.
Not indicated for the treatment of acute bronchospasm (i.e., as rescue therapy for treatment of acute episodes of bronchospasm).
Other Uses
Not indicated for treatment of asthma†; safety and efficacy in asthma not established.
Olodaterol Dosage and Administration
General
When initiating olodaterol alone or in fixed combination with tiotropium, discontinue regular use of short-acting inhaled β2-agonists; use such agents only for symptomatic relief of acute respiratory symptoms.
Failure to respond to a previously effective dosage may indicate deterioration of COPD that requires immediate reevaluation. Extra or increased dosages of olodaterol not recommended. (See Deterioration of Disease and Acute Episodes under Cautions.)
Administration
Administer olodaterol alone by oral inhalation using a specific inhaler (Striverdi Respimat) that delivers a metered-dose spray.
Administer olodaterol/tiotropium fixed combination by oral inhalation using a specific inhaler (Stiolto Respimat) that delivers a metered-dose spray.
Both inhalers deliver the drugs in an aqueous solution and mechanically produce a fine aerosol mist from the orally inhaled solution.
Administer once daily at the same time every day.
Oral Inhalation
Before first use of either Striverdi Respimat or Stiolto Respimat, place inhaler cartridge into inhaler. Consult the manufacturer's prescribing information for detailed information on inhaler preparation. Write discard date (3 months after cartridge is inserted into inhaler) on inhaler label.
Prime inhaler before first use by turning clear base in direction of black arrows on label until click is...
