Olopatadine

Class: Antiallergic Agents
- Histamine H1-receptor Antagonists
- Mast-cell Stabilizers
ATC Class: S01GX09
VA Class: OP900
Chemical Name: 11-[(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
Molecular Formula: C₂₁H₂₃NO₃•HCl
CAS Number: 140462-76-6
Brands: Pataday, Patanase, Patanol

Medically reviewed by Drugs.com on Mar 18, 2022. Written by ASHP.

Introduction

Relatively selective histamine H₁-receptor antagonist and mast-cell stabilizer.

Uses for Olopatadine

Allergic Conjunctivitis

Used ophthalmically for symptomatic management of ocular itching associated with allergic conjunctivitis.

Seasonal Allergic Rhinitis

Used intranasally to provide symptomatic relief of seasonal allergic rhinitis (e.g., hay fever).

Provides symptomatic relief of nasal congestion, rhinorrhea, nasal itching, and sneezing.

Olopatadine Dosage and Administration

Administration

Administer intranasally or topically to the eye.

Intranasal Administration

Administer intranasally twice daily, using a metered-dose nasal spray pump. Avoid spraying into the eyes.

Before initial use, prime the pump by releasing 5 sprays or until a fine mist appears. If nasal spray has not been used for >7 days, reprime the pump by releasing 2 sprays.

To actuate the pump, hold the bottle in one hand; with forefinger and middle finger on the shoulders of the pump unit and the thumb on the bottom of the bottle, press down on the shoulders of the pump to produce a fine mist.

Prior to administration, gently blow the nose to clear nasal passages. To administer, close one nostril; then, with head tipped down (chin toward chest), insert nasal applicator ¼ to ½ inch into the other nostril, hold bottle vertically upright, and aim spray tip toward the cheek side of the nose (away from the center of the nose). While gently breathing in through the nose, press f.