Opdualag

Generic name: nivolumab and relatlimab-rmbw
Dosage form: injection, for intravenous use
Drug class:Antineoplastic combinations

Medically reviewed by Judith Stewart, BPharm. Last updated on Mar 21, 2022.

What is Opdualag?

Opdualag is a prescription medicine used to treat:

• adults and children 12 years of age or older with a type of skin cancer called melanoma that has spread or cannot be removed by surgery.

It is not known if this medicine is safe and effective when used:

• in children 12 years of age or older who weigh less than 88 pounds (40 kg), or
• in children younger than 12 years of age.

Important information

Opdualag is a medicine that may treat a type of skin cancer called melanoma by working with your immune system.

Opdualag can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or can lead to death. These problems may happen anytime during treatment or even after your treatment has ended. You may have more than one of these problems at the same time.

Call or see your healthcare provider right away if you develop any new or worse signs of symptoms, including:

• Lung problems.
  • new or worsening cough
  • shortness of breath
  • chest pain
• Intestinal problems.
  • diarrhea (loose stools) or more frequent bowel movements than usual
  • stools that are black, tarry, sticky, or have blood or mucus
  • severe stomach-area (abdominal) pain or tenderness
• Liver problems.
  • yellowing of your skin or the whites of your eyes
  • severe nausea or vomiting
  • pain on the right side of your stomach area (abdomen)
  • dark urine (tea colored)
  • bleeding or bruising more easily than normal
• Hormone gland problems.
  • headaches that will not go away or unusual headaches
  • eye sensitivity to light
  • eye problems
  • rapid heartbeat
  • increased sweating
  • extreme tiredness
  • weight gain or weight loss
  • feeling more hungry or thirsty than usual
  • urinating more often than usual
  • hair loss
  • feeling cold
  • constipation
  • your voice gets deeper
  • dizziness or fainting
  • changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
• Kidney problems.
  • decrease in your amount of urine
  • blood in your urine
  • swelling in your ankles
  • loss of appetite
• Skin problems.
  • rash
  • itching
  • skin blistering or peeling
  • painful sore or ulcers in mouth or nose, throat, or genital area
• Heart problems.
  • new or worse chest pain
  • irregular heartbeat or feel like your heart is racing
  • shortness of breath
  • tiredness
  • swelling in your ankles
• Problems can also happen in other organs a..