Orenitram

Generic name:treprostinil (oral) [ tre-PROS-ti-nil ]
Drug class:Agents for pulmonary hypertension

Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.

What is Orenitram?

Orenitram dilates (widens) the arteries and decreases the amount of blood clotting platelets in your body. These effects lower blood pressure in the pulmonary artery that leads from the heart to the lungs.

Orenitram is used to treat pulmonary arterial hypertension (PAH). This medicine improves your ability to exercise.

Orenitram may also be used for purposes not listed in this medication guide.

Warnings

You should not use Orenitram if you have severe liver disease.

Before taking this medicine

You should not use Orenitram if you are allergic to treprostinil, or if you have severe liver disease.

To make sure Orenitram is safe for you, tell your doctor if you have:

• diverticulosis (an intestinal disorder); or

• liver disease.

It is not known whether Orenitram will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether treprostinil passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Orenitram?

Take Orenitram exactly as prescribed by your doctor. Follow Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Do not crush, chew, or break an extended-release tablet. Swallow the tablet whole. Do not use a broken tablet.

Take with food.

Take your doses at regular intervals to keep a steady amount of the drug in your body at all times.

You should not reduce your dose or stop using Orenitram suddenly. Stopping suddenly may make your condition worse.

Tell your doctor if you need to stop taking Orenitram for any reason. You may need an alternate treatment during that time.

Orenitram is made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a normal side effect of Orenitram and will not make the medication less effective.

Call your doctor if you have new or worsening PAH symptoms such as feeling short of breath (even with mild exertion), tiredness, chest pain, and pale skin.

Use Orenitram regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. You will probably have to use this medicine for several months or years to control your condition and keep it from getting worse.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose of Orenitram for Pulmonary Hypertension:

Oral formulation:
Initial dose: 0.25 mg orally every 12 hours with food
Recommended titration: 0.25 or 0.5 mg 2 times daily every .