OtiRx Ear Drops
Generic name:hydrocortisone, pramoxine hydrochloride, and chloroxylenol
Dosage form: ear drops
Drug class:Otic steroids with anti-infectives
Medically reviewed by Drugs.com. Last updated on Dec 22, 2021.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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OtiRx Ear Drops Description
OtiRx™ Ear Drops is an anti-inflammatory, antimicrobial and local anesthetic solution for use in the external ear only.
Each 1 mL contains:
Hydrocortisone | 10 mg |
Pramoxine Hydrochloride | 10 mg |
Chloroxylenol | 1 mg |
Inactive Ingredients: Propylene Glycol and Isopropyl Alcohol.
Hydrocortisone (Cortisol)(Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-,(11β)–.) is an anti-inflammatory and antipruritic agent. Pramoxine (Morpholine, 4-[3-(4-butoxyphenoxy) propyl]-,hydrochloride), is a topical anesthetic. Chloroxylenol (4-Chloro-3,5-xylenol) is a wide spectrum antimicrobial agent.
OtiRx Ear Drops - Clinical Pharmacology
Hydrocortisone is a corticosteroid which has anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory action of topical corticosteroids is unclear. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically-administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted...