Antitussive Hydrocodone and Homatropine

Generic name: hydrocodone bitartrate and homatropine methylbromide
Dosage form: tablet
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.

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Antitussive Hydrocodone and Homatropine Description

Hydrocodone Bitartrate and Homatropine Methylbromide Tablet, USP contains hydrocodone

(dihydrocodeinone) bitartrate, a semi synthetic centrally-acting opioid antitussive. Homatropine methylbromide is included in a subtherapeutic amount to discourage deliberate overdosage.

Each Hydrocodone Bitartrate and Homatropine Methylbromide Tablet contains:

Hydrocodone Bitartrate, USP 5 mg

Homatropine Methylbromide, USP 1.5 mg

Hydrocodone Bitartrate and Homatropine Methylbromide Tablets also contain: anhydrous lactose, dicalcium phosphate anhydrous, sodium starch glycolate, colloidal silicon dioxide and magnesium stearate.

The hydrocodone component is 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate

(1:1) hydrate (2:5), a fine white crystal or crystalline powder which is derived from the opium alkaloid, thebaine, has a molecular weight of (494.50) and may be represented by the following structural formula:

C18H21NO3• C4H6O6• 2½H2O

Hydrocodone Bitartrate

Homatropine methylbromide is 8- Azoniabicyclo[3.2.1]octane, 3-[(hydroxyphenyl-acetyl)oxy]-

8, 8-dimethyl-, bromide, endo-; a white crystal or fine white crystalline powder, with a molecular weight of (370.29).

C17H24BrNO3

Homatropine Methylbromide

Antitussive Hydrocodone and Homatropine - Clinical Pharmacology

Hydrocodone is a semisynthetic opioid antitussive and analgesic with multiple actions qualitatively similar to those ...