Oxiconazole
Class: Azoles
ATC Class: G01AF17
VA Class: DE102
Chemical Name: 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone (Z)-O-[(2,4-Dichlorophenyl)methyl]oxime mononitrate
Molecular Formula: C18H13C14N3O•HNO3
CAS Number: 64211-46-7
Brands: Oxistat
Introduction
Antifungal; azole (imidazole derivative).
Uses for Oxiconazole
Dermatophytoses
Treatment of tinea corporis (body ringworm) and tinea cruris (jock itch) caused by Epidermophyton floccosum, Microsporum canis†, M. gypseum†, Trichophyton mentagrophytes, T. rubrum, or T. verrucosum†.
Treatment of tinea pedis or tinea manuum† caused by E. floccosum, M. canis†, M. gypseum†, T. mentagrophytes, T. rubrum, or T. verrucosum†.
Topical antifungals usually effective for treatment of uncomplicated tinea corporis or tinea cruris. An oral antifungal may be necessary when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection is chronic or does not respond to topical therapy, or patient is immunocompromised because of coexisting disease or concomitant therapy.
Topical antifungals usually effective for treatment of uncomplicated tinea pedis or tinea manuum. An oral antifungal may be necessary for treatment of hyperkeratotic areas on the palms and soles, for chronic moccasin-type (dry-type) tinea pedis, and for tinea unguium (fingernail or toenail dermatophyte infections, onychomycosis).
Pityriasis (Tinea) Versicolor
Treatment of pityriasis (tinea) versicolor caused by Malassezia furfur (Pityrosporum orbiculare or P. ovale).
Topical antifungals usually effective; an oral antifungal (with or without a topical antifungal) may be necessary in patients who have extensive or severe infections or failed to respond to or have frequent relapses with topical therapy.
Cutaneous Candidiasis
Treatment of cutaneous candidiasis† caused by Candida albicans or C. tropicalis.
Oxiconazole Dosage and Administration
Administration
Topical Administration
Apply topically to the skin as a 1% cream or lotion.
Do not apply to the eye or administer intravaginally.
Avoid contact with the nose, mouth, and other mucous membranes.
Do not use with occlusive dressings or wrappings, unless otherwise directed by clinician.
Shake lotion well before using.
Apply a sufficient amount of cream or lotion; rub gently into affected area and immediately surrounding healthy skin.
Dosage
Available as oxiconazole nitrate; dosage expressed in terms of oxiconazole.
