Oxycodone and naltrexone (Oral)
Medically reviewed by Drugs.com. Last updated on Apr 28, 2022.
Misuse and abuse may lead to overdose and death. Assess risk before prescribing and regularly monitor for signs of these behaviors and conditions. Serious and potentially fatal respiratory depression may occur. Monitor for respiratory depression, particularly when initiating or increasing dosage. Instruct patients to swallow capsules whole. Do not crush, chew, or dissolve capsules. Accidental ingestion of one dose or more can lead to fatal overdose, especially in children. Prolonged use during pregnancy can lead to potentially life-threatening neonatal opioid withdrawal syndrome. Initiation of CYP3A4 inhibitors or discontinuation of CYP3A4 inducers may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse drug effects and may cause potentially fatal respiratory depression. Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of oxycodone HCl/naltrexone HCl and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required and monitor patients for signs and symptoms of respiratory depression .
Commonly used brand name(s)
In the U.S.
- Troxyca ER
Pharmacologic Class: Naltrexone
Chemical Class: Oxycodone
Uses for oxycodone and naltrexone
Oxycodone and naltrexone combination is used to relieve severe pain. It belongs to the group of medicines called narcotic analgesics (pain medicines). Oxycodone acts on the central nervous system (CNS) to relieve pain.
Oxycodone and naltrexone combination should not be used if you need pain medicine for just a short time, such as when recovering from surgery. Do not use oxycodone and naltrexone to relieve mild pain, or in situations when non-narcotic medication is effective. Oxycodone and naltrexone should not be used to treat pain that you only have once in a while or "as needed".
When oxycodone is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.
Oxycodone and naltrexone is available only with your doctor's prescription.
Before using oxycodone and naltrexone
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For oxycodone and naltrexone, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to oxycodone and naltrexone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, pre..
