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Anturane
  • Professionals
  • FDA PI

Anturane

Generic name:sulfinpyrazone
Dosage form: tablet
Drug class:Antigout agents

Medically reviewed by Drugs.com. Last updated on May 23, 2022.

Anturane®

sulfinpyrazone USP

Tablets Capsules

Prescribing Information

DESCRIPTION

Anturane, sulfinpyrazone USP, is a uricosuric agent available as 100-mg tablets and 200-mg capsules for oral administration. Its chemical name is 1,2-diphenyl-4-[2-(phenylsulfinyl) ethyl]-3,5-pyrazolidinedione, and its structural formula is

Sulfinpyrazone USP is a white to off-white powder practically insoluble in water and in solvent hexane, soluble in alcohol and in acetone, and sparingly soluble in dilute alkali. Its molecular weight is 404.48.

Inactive Ingredients. Anturane tablets: Colloidal silicon dioxide, gelatin, lactose, magnesium stearate, cornstarch, stearic acid, and talc.

Anturane capsules: D&C Red No. 33, D&C Yellow No. 10, FD&C Blue No. 1, gelatin, lactose, magnesium stearate, methylparaben, propylparaben, silicon dioxide, sodium lauryl sulfate, cornstarch, stearic acid, talc, and titanium dioxide.

CLINICAL PHARMACOLOGY

Its pharmacologic activity is the potentiation of the urinary excretion of uric acid. It is useful for reducing the blood urate levels in patients with chronic tophaceous gout and acute intermittent gout, and for promoting the resorption of tophi.

INDICATIONS

Anturane is indicated for the treatment of:

  1. Chronic gouty arthritis
  2. Intermittent gouty arthritis

Contraindications

Patients with an active peptic ulcer or symptoms of gastrointestinal inflammation or ulceration should not receive the drug.

The drug is contraindicated in patients with a history or the presence of:

  1. Hypersensitivity to phenylbutazone or other pyrazoles
  2. Blood dyscrasias

Warnings

Studies on the teratogenicity of pyrazole compounds in animals have yielded inconclusive results. Up to the present time, however, there have been no reported cases of human congenital malformation proved to be due to the use of the drug.

It is suggested that Anturane be used with caution in pregnant women, weighing the potential risks...