Pasireotide

Generic name: pasireotide [ PAS-i-REE-oh-tide ]
Brand names: Signifor, Signifor LAR
Dosage forms: intramuscular powder for injection, extended release (10 mg; 20 mg; 30 mg; 40 mg; 60 mg); subcutaneous solution (0.3 mg/mL; 0.6 mg/mL; 0.9 mg/mL)
Drug class:Somatostatin and somatostatin analogs

Medically reviewed by Drugs.com on Mar 10, 2022. Written by Cerner Multum.

What is pasireotide?

Pasireotide is a man-made protein that is similar to a hormone in the body called somatostatin.

Pasireotide is used to treat Cushing's disease or acromegaly (endocrine disorders). Pasireotide is usually given after surgery or other treatments did not work or have stopped working.

Pasireotide may also be used for purposes not listed in this medication guide.

Warnings

Pasireotide may lower your cortisol levels. Tell your doctor if you have symptoms such as nausea, vomiting, appetite changes, headache, irritability, confusion, slurred speech, or feeling weak, tired, unsteady, anxious, shaky, or light-headed.

Pasireotide can raise your blood sugar and may cause diabetes. Your blood sugar may need to be tested before and during treatment with pasireotide. Call your doctor if you have increased thirst or urination, tiredness, and weight loss even if you are more hungry than usual.

Before taking this medicine

You should not use pasireotide if you are allergic to it.

Tell your doctor if you have ever had:

• diabetes, or high blood sugar;

• liver disease;

• heart problems;

• gallstones; or

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

It is not known whether pasireotide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Pasireotide may alter hormone levels in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breast-feed while using pasireotide.

How is pasireotide given?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using pasireotide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Pasireotide is injected under the skin or into a muscle. A healthcare provider can teach you how to properly use the medication by yourself.

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