Patisiran
Generic name: patisiran [ PAT-i-SIR-an ]
Brand name: Onpattro
Dosage form: intravenous solution (2 mg/mL)
Drug class:Miscellaneous metabolic agents
What is patisiran?
Patisiran is used to treat polyneuropathy (damage of multiple nerves throughout the body) in adults with hereditary transthyretin-mediated amyloidosis (hATTR).
Patisiran may also be used for purposes not listed in this medication guide.
Warnings
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
Before using patisiran tell your doctor about all your medical conditions or allergies.
It is not known whether patisiran will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of patisiran on the baby.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
How is patisiran given?
Patisiran is given as an infusion into a vein. A healthcare provider will give you this injection once every 3 weeks.
This medicine must be given slowly, and the infusion can take about 80 minutes to complete.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when patisiran is injected.
You may be given other medications to help prevent serious side effects or an infusion reaction.
Your doctor may have you take extra vitamin A while you are using patisiran. Take only the amount of vitamin A your doctor has prescribed, especially if you are pregnant. An overdose of vitamin A can cause vision problems or other serious side effects.
Call your doctor at once if you have vision problems (especially at night) while you are taking vitamin A.
Patisiran doses are based on weight. Your dose needs may change if you gain or lose weight.
You may need frequent medical tests. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. You may also need frequent eye exams.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your patisiran injection.
What happens if I overdose?
Since patisiran is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while using patisiran?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
