Pazopanib
Generic name: pazopanib [ paz-OH-pa-nib ]
Brand name: Votrient
Dosage form: oral tablet (200 mg)
Drug class:VEGF/VEGFR inhibitors
What is pazopanib?
Pazopanib is used to treat advanced renal cell carcinoma (kidney cancer).
Pazopanib is also used to treat soft tissue sarcoma (a tumor that can develop in or around muscles, tendons, joints, organs, or blood vessels). Pazopanib is usually given after other treatments have failed.
Pazopanib may also be used for purposes not listed in this medication guide.
Warnings
Pazopanib can cause severe or life-threatening liver problems. You will need frequent blood tests to check your liver function.
Call your doctor at once if you have:nausea, vomiting, upper stomach pain, loss of appetite, tiredness, easy bruising, dark urine, or jaundice (yellowing of the skin or eyes).
Before taking this medicine
Tell your doctor if you have ever had:
heart disease, heart rhythm disorder, long QT syndrome;
a blood clot or stroke;
headaches, seizures, or vision problems;
a thyroid disorder;
kidney disease;
a perforation (a hole or tear) in your stomach or intestines;
a fistula (an abnormal passageway) within your stomach or intestines;
stomach bleeding, intestinal bleeding, or if you have coughed up blood in the past 6 months; or
a surgery (recent or planned).
You may need to have a negative pregnancy test before starting this treatment.
Both men and women using pazopanib should use effective birth control to prevent pregnancy. Pazopanib can harm an unborn baby if the mother or father is using this medicine. Keep using birth control for at least 2 weeks after your last dose.
If you are a man whose sex partner is pregnant or could become pregnant, use condoms even if you have had a vasectomy.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using pazopanib.
You should not breastfeed while you are using pazopanib, and for at least 2 weeks after your l...
