P-Care D80G
Generic name: methylprednisolone acetate, povidone-iodine, isopropyl alcohol
Dosage form: kit
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DEPO-MEDROL - methylprednisolone acetate injection, suspension
DEPO-MEDROL®
(methylprednisolone acetate injectable suspension, USP)
Pharmacia and Upjohn Company LLC
Single-Dose Vial
Not For Intravenous Use
P-Care D80G Description
DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue or intralesional injection. It is available as single-dose vials in two strengths: 40 mg/mL, 80 mg/mL.
Each mL of these preparations contains:
| Methylprednisolone acetate | 40 mg | 80 mg |
| Polyethylene glycol 3350 | 29 mg | 28 mg |
| Myristyl-gamma-picolinium chloride | 0.195 mg | 0.189 mg |
Sodium Chloride was added to adjust tonicity.
When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.
The pH of the finished product remains within the USP specified range (e.g., 3.0 to 7.0.)
The chemical name for methylprednisolone acetate is pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-6-methyl-,(6α,11β)- and the molecular weight is 416.51. The structural formula is represented below:
Methylprednisolone Acetate Structural Formula
DEPO-MEDROL Sterile Aqueous Suspension contains methylprednisolone acetate which is the 6-methyl derivative of prednisolone. Methylprednisolone acetate is a white or practically white, odorless, crystalline powder which melts at about 215° with some decomposition. It is soluble in dioxane, sparingly soluble in acetone, alcohol, chloroform, and methanol, and slightly soluble in ether. It is practically insoluble in water.
CLINICAL PHARMACOLOGY
Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids.
Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt retaining properties, are used in replacement therapy in adrenocortical deficiency states. Their synthetic analogs are ..
