Pedi-Dri Powder
Generic name:nystatin
Dosage form: powder
Drug class:Topical antifungals
Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.
On This Page
Rx only
For topical use only.
Not for ophthalmic use.
The Pedi-Dri brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Pedi-Dri Powder Description
PEDI-DRI®, Nystatin Topical Powder USP is for dermatologic use.
PEDI-DRI® provides, in each gram, 100,000 USP nystatin units dispersed in talc.
Nystatin is a polyene antifungal antibiotic obtained from Streptomyces nursei.
Pedi-Dri Powder - Clinical Pharmacology
Pharmacokinetics
Nystatin is not absorbed from intact skin or mucous membrane.
Microbiology
Nystatin is an antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C. parapsilosis, C. tropicalis, C. guilliermondi, C. pseudotropicalis, C. krusei, Torulopsis glabrata, Tricophyton rubrum, T. mentagrophytes.
Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Generally, resistance to nystatin does not develop during therapy. However, other species of Candida (c. tropicalis, C. guilliermondi, C. krusei, and C. stalltoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. This resistance is lost when the antibiotic is removed. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses.
