Pegademase bovine (Intramuscular)

Medically reviewed by Drugs.com. Last updated on Mar 21, 2022.

Commonly used brand name(s)

In the U.S.

• Adagen

Pharmacologic Class: Enzyme

Uses for pegademase bovine

Pegademase contains an enzyme called adenosine deaminase (ADA). It is used to treat children who do not have a properly developed immune system because of a lack of ADA in the body.

Pegademase is to be given only by or under the supervision of your doctor.

Before using pegademase bovine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pegademase bovine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to pegademase bovine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of pegademase in children.

Geriatric

No information is available on the relationship of age to the effects of pegademase in geriatric patients.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking pegademase bovine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using pegademase bovine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Pentostatin

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems may affect the use of pegademase bovine. Make sure you tell your doctor if you have any other medical problems, especially:

• Bleeding problems (e.g., thrombocytopenia) or
• Infections—Use with caution. May make these conditions worse.

• Thrombocytopenia, severe—Should not be used in patients with this condition.

Proper use of pegademase bovine

A nurse or other trained health professional will give you or you...