Pentothal

Generic name:thiopental sodium
Dosage form: injection, powder, for solution
Drug class:General anesthetics

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

THIOPENTAL SODIUMFOR INJECTION

CIII

Rx only

Pentothal Description

Pentothal (Thiopental Sodium for Injection) is a thiobarbiturate, the sulfur analogue of sodium pentobarbital.

The drug is prepared as a sterile powder and after reconstitution with an appropriate diluent is administered by the intravenous route.

Pentothal is chemically designated sodium 5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate and has the following structural formula:

The drug is a yellowish, hygroscopic powder, stabilized with anhydrous sodium carbonate as a buffer (60 mg/g of thiopental sodium).

Pentothal - Clinical Pharmacology

Pentothal (Thiopental Sodium for Injection) is an ultrashort-acting depressant of the central nervous system that induces hypnosis and anesthesia, but not analgesia. It produces hypnosis within 30 to 40 seconds of intravenous injection. Recovery after a small dose is rapid, with some somnolence and retrograde amnesia. Repeated intravenous doses lead to prolonged anesthesia because fatty tissues act as a reservoir; they accumulate Pentothal in concentrations 6 to 12 times greater than the plasma concentration, and then release the drug slowly to cause prolonged anesthesia.

The half-life of the elimination phase after a single intravenous dose is three to eight hours.

The distribution and fate of Pentothal (as with other barbiturates) is influenced chiefly by its lipid solubility (partition coefficient), protein binding and extent of ionization. Pentothal has a partition coefficient of 580.

Approx...