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Aplenzin
  • Treatments
  • Depression

Aplenzin

Generic name:bupropion hydrobromide extended-release tablets
Drug class:Miscellaneous antidepressants

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 21, 2022.

What is Aplenzin?

Aplenzin is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder.

Aplenzin may also be used for purposes not listed in this medication guide.

Warnings

You should not take Aplenzin if you have seizures, an eating disorder, or if you have suddenly stopped using alcohol, seizure medication, or sedatives. If you take Aplenzin for depression, do not also take Zyban to quit smoking.

Do not use bupropion if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Aplenzin may cause seizures, especially in people with certain medical conditions or when using certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using Aplenzin. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Before taking this medicine

Do not use Aplenzin if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not take Aplenzin if you are allergic to bupropion, or if you have:

  • a seizure disorder;
  • an eating disorder such as anorexia or bulimia; or

    if you have suddenly stopped using alcohol, seizure medication, or a sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Do not take Aplenzin to treat more than one condition at a time. If you take Aplenzin for depression, do not also take Zyban to quit smoking.

Aplenzin may cause seizures, especially if you have certain medical conditions or use certain drugs. Tell your doctor about all of your medical conditions and the drugs you use.

To make sure Aplenzin is safe for you, tell your doctor if you have ever had:

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