Pergolide
Generic name: Pergolide mesylate
Dosage form: tablet
Drug class:Dopaminergic antiparkinsonism agents
Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.
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Pergolide Description
Pergolide mesylate is an ergot derivative dopamine receptor agonist at both D1 and D2 receptor sites. Pergolide mesylate is chemically designated as 8ß[(methylthio)methyl]-6-propylergoline monomethanesulfonate; the structural formula is as follows:
The empirical formula is C19H26N2S•CH4O3S, representing a molecular weight of 410.60.
Pergolide mesylate is provided for oral administration in tablets containing 0.05 mg (0.159 µmol), 0.25 mg (0.795 µmol), or 1 mg (3.18 µmol) Pergolide as the base. The tablets also contain lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch and sodium starch glycolate. The 0.05 mg tablet also contains ferric oxide yellow. The 0.25 mg tablet also contains FD&C Blue No. 2 aluminum lake and ferric oxide yellow. The 1 mg tablet also contains ferric oxide red.
Pergolide - Clinical Pharmacology
Pharmacodynamic Information
Pergolide mesylate is a potent dopamine receptor agonist. Pergolide is 10 to 1000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In Parkinson’s disease, Pergolide mesylate is believed to exert its therapeutic effect by directly stimulating post-synaptic dopamine receptors in the nigrostriatal system.
