Phenylephrine, Carbetapentane, Potassium Guaiacolsulfonate

Dosage form: liquid
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Phenylephrine, Carbetapentane, Potassium Guaiacolsulfonate Description

Phenylephrine 10 mg/Carbetapentane 20 mg/Potassium Guaiacolsulfonate 100 mg/5 mL is an alcohol free, dye free, sugar free, clear and colorless liquid with a raspberry mint scent and flavor.
Each 5mL (1 teaspoonful) for oral administration contains:
Phenylephrine hydrochloride .....10 mg
Carbetapentane citrate ..... 20 mg
Potassium guaiacolsulfonate .....100 mg
Inactive ingredients: sodium citrate, citric acid, sodium saccharin, sorbitol, glycerin, propylene glycol, deionized water, menthol mint and raspberry flavor.

Phenylephrine hydrochloride is an orally effective nasal decongestant having the chemical name, benzenemethanol, 3-hydroxy-α−[(methylamino)methyl]-hydrochloride, an adrenergic which occurs as white or practically white, odorless crystals, having a bitter taste. It is freely soluble in water and in alcohol. The structural formula is:



Carbetapentane citrate or, 1-Phenylcyclopentane-carboxylic acid, 2-(2-diethylaminoethoxy) ethyl ester citrate, is a white crystalline powder. It is freely soluble in water and chloroform. Its structure is as follows:



Chemically, potassium guaiacolsulfonate is benzene-sulfonic acid, hydroxy-methoxy-, monopotassium salt, hemihydrate with the following structure:

Phenylephrine, Carbetapentane, Potassium Guaiacolsulfonate - Clinical Pharmacology

Phenylephrine HCI:
Phenylephrine HCI, a nasal decongestant, is a potent postsynaptic alpha-receptor agonist with little effect on the beta receptors of the bronchi or peripheral blood vessels. Therapeutic doses of phenylephrine HCl may cause va