Acetaminophen, chlorpheniramine, and phenylephrine

Generic name: acetaminophen, chlorpheniramine, and phenylephrine [ a-SEET-a-MIN-oh-fen, KLOR-fen-EER-a-meen, FEN-ill-EFF-rin ]
Brand names: Alka-Seltzer Plus Cold, Comtrex Severe Cold & Sinus, Contac Cold+Flu Maximum Strength, Dristan Cold Multi Symptom Formula, Robitussin Nighttime Nasal Relief, ... show all 19 brands Tylenol Allergy Multi-Symptom, Tylenol Children's Plus Cold, Tylenol Sinus Congestion Nighttime, Gendecon, Protid, Dryphen, Comtrex Severe Cold and Sinus, Comtrex Flu Therapy, Sinus Congestion and Pain Nighttime, Allergy Relief Multi-Symptom, Tylenol Sinus Congestion-Pain Cool Burst, Norel AD, Relief-PE, Contact Cold and Flu Night
Dosage forms: oral kit (varying strength); oral liquid (160 mg-1 mg-2.5 mg/5 mL); oral tablet (325 mg-2 mg-5 mg; 325 mg-4 mg-10 mg; 500 mg-2 mg-5 mg); oral tablet, effervescent (250 mg-2 mg-5 mg)
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com on Feb 1, 2022. Written by Cerner Multum.

What is acetaminophen, chlorpheniramine, and phenylephrine?

Acetaminophen is a pain reliever and fever reducer.

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Acetaminophen, chlorpheniramine, and phenylephrine is a combination medicine used to treat headache, fever, body aches, runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Acetaminophen, chlorpheniramine, and phenylephrine may also be used for purposes not listed in this medication guide.

Warnings

Do not use acetaminophen, chlorpheniramine, and phenylephrine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, line