Plasma Protein Fraction

Class: Blood Derivatives
ATC Class: B05AA
VA Class: BL500
CAS Number: 55963-80-9
Brands: Plasmanate

Medically reviewed by Drugs.com on Jul 22, 2021. Written by ASHP.

Introduction

Protein colloid; sterile solution of selected proteins prepared from pooled human plasma.

Uses for Plasma Protein Fraction

Fluid Resuscitation (Shock)

Used for plasma volume expansion in the treatment of certain types of shock, including shock resulting from burns, crushing injuries, abdominal emergencies, or any other cause where there is a predominant loss of plasma fluids and not RBCs.

Adequate replacement for human plasma in the treatment of shock and suitable means of providing human proteins for their osmotic effect; however, albumin solutions may be preferable because they contain a greater percentage of albumin and, since they are more purified, are less likely to cause hypotensive reactions. (See Hypotension under Cautions.)

Initial therapy in infants and small children for shock resulting from dehydration and infection.

Emergency treatment of shock due to hemorrhage. Following the emergency phase of therapy, transfusions of whole blood or RBCs may be indicated, depending on the severity of the blood loss.

Plasma Protein Fraction Dosage and Administration

Administration

IV Administration

Administer by IV infusion, preferably at a site at some distance from any site of infection or trauma.

Swab the rubber stopper on vial with iodine tincture followed by a sterile antiseptic swab. Insert a 16-gauge needle or dispensing pin perpendicular to the stopper in the area delineated by a raised ring.

Does not contain preservatives; discard any partially used vials.

Do not mix with protein hydrolysates or solutions containing alcohol.

To minimize administration errors, consult the manufacturer’s administration instructions for proper use.

Rate of Administration

Adjust rate of infusion according to the clinical response of the patient and changes in BP.

For hypovolemic shock in infants and young children: Infusion at a rate of up to 5–10 mL/minute has been suggested.

As plasma volume approaches normal, do not exceed 5–8 mL/minute. Rapid IV infusion (e.g., >10 mL/minute) may cause vascular overload. (See Infusion Effects under Cautions.)

Dosage

Dosage depends on the patient’s condition and response to therapy.

Pediatric Patients

Fluid Resuscitation (Shock)

Hypovolemic Shock

Infants and young children: Initially, 6.6–33 mL/kg (0.33–1.65 g/kg of protein). Subsequent dosage is determined by the patient’s condition.

Adults

Fluid Resuscitation (Shock)

Hypovolemic Shock

Usual minimum effective dosage: 250–500 mL (12.5–25 g of protein). Subsequent dosage is determined by the patient’s condition.

Prescribing Limits

Adults

Fluid Resuscitation (Shock)

Hypovolemic Shock

Do not exceed 5–8 mL/minute.

Special Populations

No special population dosage recommendations at this time.