Plazomicin (Intravenous)
Medically reviewed by Drugs.com. Last updated on Mar 3, 2022.
Warning: Nephrotoxicity, Ototoxicity, Neuromuscular Blockade and Fetal HarmNephrotoxicity has been reported with plazomicin. The risk of nephrotoxicity is greater in patients with impaired renal function, the elderly, and in those receiving concomitant nephrotoxic medications. Assess creatinine clearance in all patients prior to initiating therapy and daily during therapy. Therapeutic drug monitoring (TDM) is recommended for complicated urinary tract infection (cUTI) patients with CrCl less than 90 mL/min to avoid potentially toxic levels.Ototoxicity, manifested as hearing loss, tinnitus, and/or vertigo, has been reported with plazomicin. Symptoms of aminoglycoside-associated ototoxicity may be irreversible and may not become evident until after completion of therapy. Aminoglycoside-associated ototoxicity has been observed primarily in patients with a family history of hearing loss, patients with renal impairment, and in patients receiving higher doses and/or longer durations of therapy than recommended.Aminoglycosides have been associated with neuromuscular blockade. During therapy with plazomicin, monitor for adverse reactions associated with neuromuscular blockade, particularly in high-risk patients, such as patients with underlying neuromuscular disorders (including myasthenia gravis) or in patients concomitantly receiving neuromuscular blocking agents.Aminoglycosides, including plazomicin, can cause fetal harm when administered to a pregnant woman .
Commonly used brand name(s)
In the U.S.
- Zemdri
Available Dosage Forms:
- Solution
Therapeutic Class: Antibiotic
Chemical Class: Aminoglycoside
Uses for plazomicin
Plazomicin is used to treat complicated urinary tract infections (cUTI), including pyelonephritis (kidney infection) in patients who have limited or no other treatment options. Plazomicin is an aminoglycoside antibiotic that works by killing bacteria or preventing their growth.
Plazomicin may be given only by or under the direct supervision of your doctor.
Before using plazomicin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For plazomicin, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to plazomicin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of plazomicin in the pediatric population. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of plazomicin in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution for patients receiving plazomicin.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication..
