Pluvicto

Generic name:lutetium Lu 177 vipivotide tetraxetan
Dosage form: injection, for intravenous use
Drug class:Therapeutic radiopharmaceuticals

Medically reviewed by Judith Stewart, BPharm. Last updated on Apr 13, 2022.

What is Pluvicto?

Pluvicto is a targeted radiopharmaceutical treatment for the treatment of adult patients with a certain type of advanced cancer called prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer (PSMA-positive mCRPC) that has spread to other parts of the body.

Pluvicto is used in patients who have already been treated with other anti-cancer treatments.

Patients will need a scan before receiving Pluvicto, using Locametz or another approved PSMA-11 imaging agent to identify the PSMA-positive lesions.

Warnings

Pluvicto may cause harm to an unborn baby.

Men with female partners should use effective contraception for intercourse during treatment with Pluvicto, and for 14 weeks after the last dose.

Pluvicto may cause temporary or permanent infertility in males.

Pluvicto contributes to your overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk for cancer.

To minimize radiation exposure to others after you receive Pluvicto

• you should limit close contact (less than 3 feet) with household contacts for 2 days or with children and pregnant women for 7 days
• you should refrain from sexual activity for 7 days
• you should sleep in a separate bedroom from household contacts for 3 days, from children for 7 days, and from pregnant women for 15 days.

Pluvicto can cause severe and life-threatening myelosuppression, including anemia, thrombocytopenia, leukopenia, and neutropenia. 

Pluvicto can cause severe renal toxicity. You should remain well hydrated and urinate frequently before and after administration of Pluvicto to prevent kidney injury. You will receive kidney function tests before and during your treatment.

Who should not receive Pluvicto?

You should not receive Pluvicto if you are allergic to lutetium Lu 177 vipivotide tetraxetan.

Before you receive Pluvicto

Before you receive Pluvicto, tell your doctor if you:

• have low blood cell counts (hemoglobin, white blood cell count, absolute neutrophil count, platelet count)
• have signs of myelosuppression (tiredness, weakness, pale skin, shortness of breath, bleeding or bruising more easily than normal or difficulty stopping bleeding, or frequent infections with signs such as fever, chills, sore throat, or mouth ulcers)
• have kidney problems
• have any other type of cancer or treatment for cancer. Pluvicto contributes to long-term cumulative radiation exposure.
• have a female partner who is pregnant or planning to become pregnant. All radiopharmaceuticals, including Pluvicto, have the potential to cause harm to an unborn baby. Patients should use effective contraception for intercourse during treatment with Pluvicto, and for 14 weeks after the l...