Podophyllum Resin
Class: Skin and Mucous Membrane Agents, Miscellaneous
- Antimitotic Agents
VA Class: DE500
CAS Number: 8050-60-0
Brands: Podocon-25
Introduction
Antimitotic; caustic agent.
Uses for Podophyllum Resin
Human Papillomavirus (HPV) Infections
Topical treatment of external genital and perianal exophytic warts (condylomata acuminata) caused by HPV.
CDC and others recommend that external HPV warts be treated with a self-administered topical therapy (podofilox, imiquimod), a topical therapy administered by a health-care provider (podophyllum resin, trichloroacetic acid [TCA], bichloroacetic acid [BCA]), or a surgical technique (cryotherapy, electrosurgery, surgical excision). Alternative therapies include intralesional interferon alfa or laser surgery.
A preferred treatment for external genital HPV warts in adults and adolescents with HIV infection when complex or multicentric lesions are present or lesions are inaccessible to patient-applied treatments (e.g., podofilox 0.5%, imiquimod 5%). An alternative treatment for external genital HPV warts in HIV-infected children†; topical therapies often are ineffective in such children, and a surgical technique (cryotherapy, electrosurgery) may be preferred.
Primary goal is destruction or clearance of visible, symptomatic warts. No regimen has been shown to eradicate HPV or affect natural history of HPV infection; effect on transmission of HPV unknown.
Do not use to treat subclinical genital HPV infection (without exophytic warts).
Topical treatment of urethral meatus HPV warts†. CDC recommends cryotherapy or topical podophyllum resin (10–25% solution in benzoin tincture).
Not included in CDC recommendations for treatment of intravaginal, cervical, rectal, or anal HPV warts.
Podophyllum Resin Dosage and Administration
Administration
Topical Administration
Apply topically as a solution containing 10–25% podophyllum resin in benzoin tincture.
Solutions containing 10–25% podophyllum resin in benzoin tincture should only be applied by a health-care provider and should not be dispensed to the patient. Solutions containing lower concentrations of podophyllum resin (e.g., 0.5–2% ethanolic solutions) have been prepared extemporaneously for self-administration by patients, but safety and efficacy not established.
For external use only; avoid contact with eyes. (See Administration Precautions under Cautions.)
Prior to application, wash affected area. Shake solution well prior to each use.
Apply solution sparingly to intact HPV warts and allow to air dry. Do not apply to bleeding warts, moles, birthmarks, unusual warts with hair growing from them, or warts that have recently been biopsied. Do not apply to normal tissue or mucous membranes.
Adjacent skin may be protected by applying petrolatum or flexible collodion prior to application of the drug.
Immediately following prescribed period of treatment, thoroughly remove ..
