Polivy

Generic name:polatuzumab vedotin [ POL-a-TOOZ-use-mab-ve-DOE-tin ]
Drug class:Miscellaneous antineoplastics

Medically reviewed by Drugs.com on Jan 4, 2021. Written by Cerner Multum.

What is Polivy?

Polivy is used to treat diffuse large B-cell lymphoma after at least two other cancer treatments did not work or have stopped working.

Polivy is given in combination with bendamustine (Bendeka, Treanda) and a medicine that contains rituximab (Rituxan).

Polivy may also be used for purposes not listed in this medication guide.

Warnings

Polivy affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, unusual bleeding or bruising, burning when you urinate, or problems with speech, thought, or muscle movement.

Before taking this medicine

Tell your doctor if you have ever had:

• liver disease; or

• nerve problems (neuropathy) in your hands and feet.

Polivy can harm an unborn baby or cause birth defects if the mother or the father is using Polivy.

• If you are a woman, you may need to have a negative pregnancy test before starting this treatment. Do not use Polivy if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 months after your last dose.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 5 months after your last dose.

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Polivy.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because Polivy can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 2 months after your last dose.

How should I take Polivy?

Polivy is given as an infusion into a vein. A healthcare provider will give you this injection.

Polivy is usually given once every 21 days, along with bendamustine and rituximab. Your doctor will determine how long to treat you with these medicines.

You may be given other medications to help prevent serious side effects, allergic reaction, or infections. Keep using these medicines for as long as your doctor has prescribed.

Polivy affects your immune system. You may get infections more easily, even serious or fatal infections. Your blood will need to be tested ofte...