Apomorphine (Sublingual)

Medically reviewed by Drugs.com. Last updated on Mar 28, 2022.

Commonly used brand name(s)

In the U.S.

• Kynmobi

Available Dosage Forms:

• Film

Therapeutic Class: Antiparkinsonian

Pharmacologic Class: Apomorphine

Uses for apomorphine

Apomorphine sublingual film is used to treat short-term (acute), intermittent “off” episodes in patients with Parkinson’s disease. By improving muscle control and reducing stiffness, apomorphine allows more normal movements of the body as the symptoms of the disease are reduced.

Apomorphine is available only with your doctor's prescription.

Before using apomorphine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For apomorphine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to apomorphine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of apomorphine sublingual film in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of apomorphine sublingual film in the elderly. However, elderly patients are more likely to have serious unwanted effects (eg, confusion, hallucination, heart or blood vessel problems, falls, stomach or bowel problems, lung or breathing problems) and age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients using apomorphine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking apomorphine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using apomorphine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Alosetron
• Bepridil
• Cisapride
• Dolasetron
• Dronedarone
• Granisetron
• Levoketoconazole
• Mesoridazine
• Ondansetron
• Palonosetron
• Piperaquine
• Saquinavir
• Sparfloxacin
• Sulpiride
• Terfenadine
• Thioridazine
• Ziprasidone

Using apomorphine with any of the following medicines is usually not recommended, but may be required...