Pralatrexate
Generic name: pralatrexate [ PRAL-a-TREX-ate ]
Brand name: Folotyn
Dosage form: intravenous solution (20 mg/mL)
Drug class:Antimetabolites
What is pralatrexate?
Pralatrexate is used to treat T-cell lymphoma that has spread throughout the body.
Pralatrexate is usually given after other treatments have failed.
Pralatrexate may also be used for purposes not listed in this medication guide.
Warnings
Pralatrexate can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, body aches).
Before taking this medicine
Tell your doctor if you have ever had liver or kidney problems.
You may need to have a negative pregnancy test before starting this treatment.
Pralatrexate can harm an unborn baby if the mother or the father is using pralatrexate.
If you are a woman, do not use pralatrexate if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using pralatrexate.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
How is pralatrexate given?
Pralatrexate is given as an infusion into a vein. A healthcare provider will give you this injection.
Pralatrexate is usually given once per week for up to 6 weeks at a time.
Your doctor may have you take folic acid supplements before, during, and after your treatment with pralatrexate. You may also receive vitamin B12 injections every 8 to 10 weeks. This can help protect your blood cells from certain side effects of pralatrexate.
Follow your doctor's dosing instructions very carefully.
Pralatrexate can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your pralatrexate injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving pralatrexate?
Do not receive a "live" vaccine whil...
