Pralidoxime Chloride

Dosage form: Injection
Drug class:Antidotes

Medically reviewed by Drugs.com. Last updated on May 23, 2022.

FOR USE IN NERVE AGENT POISONING ONLY

A Sterile Solution For Intramuscular Use Only

Rx Only

Pralidoxime Chloride Description

Pralidoxime Chloride Injection (auto-injector) provides Pralidoxime Chloride in a sterile solution for intramuscular injection.

Each prefilled auto-injector provides a dose of the antidote, Pralidoxime Chloride in a self-contained unit, specially designed for automatic self- or buddy-administration by military personnel. Pralidoxime in the auto-injector may also be administered by qualified civilian emergency responders who have had adequate training in the on-site recognition and treatment of nerve agent intoxication in the event of an accidental release of nerve agent. The recommended procedure (see DOSAGE AND ADMINISTRATION) is to inject the contents of the auto-injector into the muscles of an outer thigh.

After an auto-injector has been activated, the empty container should be disposed of properly (see DOSAGE AND ADMINISTRATION), it cannot be refilled nor can the protruding needle be retracted.

When activated, each auto-injector dispenses 600 mg of Pralidoxime Chloride in 2 mL of a sterile solution containing 20 mg/mL benzyl alcohol, 11.26 mg/mL glycine in Water for Injection, USP. The pH is adjusted with hydrochloric acid. The pH range is 2.0-3.0. The product is pyrogen free.

Pralidoxime Chloride is a cholinesterase reactivator.

Chemical Name: 2-formyl-1 methylpyridinium chloride oxime (pyridine-2-aldoxime methochloride). Also referred to as 2-PAM Chloride.

Structural Formula:

Pralidoxime Chloride occurs as an odorless, white, nonhygroscopic, crystalline powder which is soluble in water to the extent of 1 g in less than 1 mL. Stable in air, it melts between 215°C and 225°C, with decomposition.

The specific activity of the drug re...