Prascion Cleanser

Generic name:sodium sulfacetamide and sulfur
Dosage form: topical soap
Drug class:Topical antibiotics

Medically reviewed by Drugs.com. Last updated on Jul 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

DESCRIPTION:
Each gram of PRASCION (sodium sulfacetamide 10% and sulfur 5%) Cleanser contains 100 mg of Sodium Sulfacetamide USP and 50 mg of Sulfur USP in a cleanser base containing Purified Water USP, Sodium Methyl Cocoyl Taurate, Disodium Oleamido MEA Sulfosuccinate, Sodium Cocoyl Isethionate, Cetyl Alcohol NF, Glyceryl Stearate (and) PEG 100 Stearate, Stearyl Alcohol NF, Magnesium Aluminum Silicate NF, Disodium EDTA USP, Methylparaben NF, Butylated Hydroxytoluene NF, Sodium Thiosulfate USP, Xanthan Gum NF, Fragrance, Propylparaben NF.

Sodium sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent. Chemically sodium sulfacetamide is N-[(4-aminophenyl) sulfonyl]-acetamide, monosodium salt, mono-hydrate. The structural formula is:

CLINICAL PHARMACOLOGY:
The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours. The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.

INDICATIONS:
PRASCION (sodium sulfacetamide 10% and
sulfur 5%) Cleanser is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.

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