Prascion RA with Sunscreens Cream

Generic name:sodium sulfacetamide and sulfur
Dosage form: cream
Drug class:Topical antibiotics

Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Rx only
DESCRIPTION: Each gram of Prascion® RA Cream With Sunscreens contains 100 mg of sodium sulfacetamide and 50 mg of sulfur in a cream containing avobenzone, benzyl alcohol NF, cetyl alcohol NF, cocoglycerides, dimethicone 200/100, edetate disodium USP, fragrance, glyceryl stearate/Peg-100 stearate, isopropyl myristate NF, light mineral oil NF, octinoxate USP, polysorbate 60 NF, propylene glycol USP, purified water USP, sodium thiosulfate USP, sorbitan monostearate NF, stearyl alcohol NF, xanthan gum NF.

Sodium sulfacetamide is a sulfonamide with antibacterial activity while sulfur acts as a keratolytic agent. Chemically, sodium sulfacetamide is N-[(4-aminophenyl) sulfonyl]-acetamide, monosodium salt, monohydrate. The structural formula is:

CLINICAL PHARMACOLOGY: The most widely accepted mechanism of action of sulfonamides is the Woods-Fildes theory, which is based on the fact that sulfonamides act as competitive antagonists to para-aminobenzoic acid (PABA), an essential component for bacterial growth. While absorption through intact skin has not been determined, sodium sulfacetamide is readily absorbed from the gastrointestinal tract when taken orally and excreted in the urine, largely unchanged. The biological half-life has variously been reported as 7 to 12.8 hours.

The exact mode of action of sulfur in the treatment of acne is unknown, but it has been reported that it inhibits the growth of Propionibacterium acnes and the formation of free fatty acids.

INDICATIONS AND USAGE: Prascion RA Cream With Sunscreens is indicated in the topical control of acne vulgaris, acne rosacea and seborrheic dermatitis.

CONTRAINDICATIONS: Prascion RA Cream With Sunscreens is contraindicated for use by patients having known h.