Pred-G Ophthalmic Suspension

Generic name:gentamicin sulfate and prednisolone acetate
Dosage form: ophthalmic suspension
Drug class:Ophthalmic steroids with anti-infectives

Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.

Pred-G Ophthalmic Suspension Description

PRED-G® sterile ophthalmic suspension is a topical anti-inflammatory/anti-infective combination product for ophthalmic use.

Structural Formulae:

prednisoloneacetategentamicinsulfate

Chemical Names: Prednisolone acetate: 11ß,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate.

Gentamicin sulfate is the sulfate salt of gentamicin C1, gentamicin C2, and gentamicin C1A which are produced by the growth of Micromonospora purpurea.

Contains: Actives: Gentamicin sulfate equivalent to 0.3% gentamicin base; prednisolone acetate (microfine suspension) 1%. Preservative: Benzalkonium chloride 0.005%. Inactives: edetate disodium; hypromellose; polyvinyl alcohol 1.4%; polysorbate 80; purified water; sodium chloride; and sodium citrate, dihydrate. May contain sodium hydroxide and/or hydrochloric acid to adjust pH (5.4 to 6.6).

PRED-G® suspension is formulated with a pH from 5.4 to 6.6 and its osmolality ranges from 260 to 340 mOsm/kg.

Pred-G Ophthalmic Suspension - Clinical Pharmacology

Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.

The anti-infective component in PRED-G® is included to provide action against specific organisms susceptible to it. Gentamicin sulfate is active in vitro against susceptible strains of the following microorganisms: Staphylococcus aureus, Streptococcus pyogenes...