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Premarin Vaginal
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Premarin Vaginal Cream

Generic name:conjugated estrogens (vaginal) [ KON-joo-gay-ted-ES-troe-jenz ]
Drug classes:Estrogens, Miscellaneous vaginal agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 21, 2022.

What is Premarin Vaginal Cream?

Premarin Vaginal Cream contains a mixture of estrogen hormones. Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.

Premarin Vaginal Cream is used in the vagina to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

Premarin Vaginal may also be used for purposes not listed in this medication guide.

Warnings

Do not use Premarin Vaginal Cream if you are pregnant.

You should not use Premarin Vaginal Cream if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will be having major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Use Premarin Vaginal may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Estrogen should not be used to prevent heart disease, stroke, or dementia.

Before taking this medicine

You should not use Premarin Vaginal Cream if you have:

  • unusual vaginal bleeding that has not been checked by a doctor;

  • liver disease;

  • a history of heart attack, stroke, or blood clot;

  • an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or

  • a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.

Do not use Premarin Vaginal if you are pregnant. Use effective birth control if you are not past menopause. Tell your doctor if you think you may be pregnant.

Premarin Vaginal Cream can weaken the latex of a condom, diaphragm, or cervical cap. Talk to your doctor about the best birth control methods to use.

Using Premarin Vaginal can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have

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